Metformin-Associated Lactic Acidosis
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منابع مشابه
Metformin-Associated Lactic Acidosis
Metformin has been used in Europe since the 1970s to treat type 2 diabetes mellitus (T2DM). Usage has increased since the results of the UK Prospective Diabetes Study were published [1]. Metformin is widely endorsed as initial therapy by professional organizations because of low cost, a good safety profile, and potential protection against cardiovascular disease [2]. Therefore, it is now consid...
متن کاملMetformin-associated lactic acidosis.
: Metformin is the most commonly prescribed oral antidiabetic agent. Despite a good safety profile in most patients with diabetes, the risk of metformin-associated lactic acidosis is real if safety guidelines are ignored. Experience with 3 cases of metformin-associated lactic acidosis is reported. Two cases were caused by inappropriate use of metformin in the presence of renal, cardiac and hepa...
متن کاملMetformin-Associated Lactic Acidosis: A Case Report
A 54-year-old woman with type 2 diabetes mellitus, hypertension, and peripheral vascular disease developed life-threatening lactic acidosis during treatment with metformin for type 2 diabetes. The woman received metformin at 1000 mg orally twice a day for type 2 diabetes. She presented to our emergency department with a 3-day history of severe watery diarrhea, nausea, and vomiting. Her grandson...
متن کاملMetformin and Lactic Acidosis
Probably the most common mechanism by which metformin elevates blood lactate is by inducing catecholamine release in those who regulate or prescribe it. Caution in restricting the use of metformin for the treatment of type 2 diabetes has been rationalized on the basis of J) its chemical identity as a biguanide, 2) its ability to modify hepatic intermediary metabolism, 3) its administration to i...
متن کاملBerberine protects against metformin-associated lactic acidosis in induced diabetes mellitus
Objective(s): Causality of occurrence of metformin-associated lactic acidosis (MALA) is a clinical problem. Currently, there is no drug available to prevent MALA. The present study was conducted to evaluate the protective effect of Berberine (BBR) against MALA in induced diabetic rat model. Materials and Methods: A sample of 75 healthy male Wistar rats was randomly selected according to inclusi...
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ژورنال
عنوان ژورنال: Endocrinology and Metabolism
سال: 2015
ISSN: 2093-596X,2093-5978
DOI: 10.3803/enm.2015.30.1.45